Advanced Oncology Certified Nurse Practitioner (AOCNP) Certification Practice Test 2026 - Free AOCNP Practice Questions and Study Guide

The targeted urine output during the management of tumor lysis syndrome (TLS) is generally set between 150-200 ml/hr. This range is considered optimal for ensuring adequate hydration and preventing complications associated with TLS, such as acute kidney injury. Maintaining this level of urine output helps facilitate the excretion of elevated levels of potassium, phosphorus, and uric acid that can occur as tumor cells break down rapidly, especially following chemotherapy.

Achieving a urine output in this range helps to dilute these electrolytes and toxins, reducing the risk of metabolic derangements. It is also critical to monitor fluid status closely and adjust hydration accordingly, as individual patient needs may vary based on their overall condition, degree of hyperuricemia, and specific treatment regimens. Targeting a urine output below this range may not provide sufficient clearance of the byproducts of cell lysis, while a significantly higher output could lead to unnecessary fluid overload, particularly in patients with renal impairment or cardiac comorbidities.