Advanced Oncology Certified Nurse Practitioner (AOCNP) Certification Practice Test 2026 - Free AOCNP Practice Questions and Study Guide

HER2, or human epidermal growth factor receptor 2, is a protein found on the surface of some cancer cells, including certain types of breast cancer. Its significance lies primarily in its role in cancer cell growth and proliferation. When HER2 is overexpressed, it can lead to more aggressive forms of cancer, resulting in a poorer prognosis if left untreated.

The overexpression of the HER2 protein serves as a biomarker that can guide treatment decisions. In cases where HER2 is found to be overexpressed, targeted therapies such as trastuzumab (Herceptin) or other HER2 inhibitors can be utilized to improve outcomes. These treatments specifically target the HER2-positive cells, thereby inhibiting their growth and division, which is pivotal for effective management of HER2-positive breast cancer.

This distinction in treatment options based on HER2 status illustrates its clinical importance, making the identification of HER2 overexpression a critical part of the diagnostic process in breast cancer care. Such targeted therapies have transformed the treatment landscape for HER2-positive breast cancer, leading to increased survival rates and better quality of life for patients.

Other statements lack accuracy in reflecting the role of HER2 in breast cancer management. For instance, HER2's relevance in deciding treatment