Advanced Oncology Certified Nurse Practitioner (AOCNP) Certification Practice Test 2025 - Free AOCNP Practice Questions and Study Guide

In Tumor Lysis Syndrome (TLS), phosphorus plays a significant role due to the rapid breakdown of tumor cells, which releases large quantities of intracellular substances into the bloodstream, including phosphate. As a result, elevated levels of phosphate can lead to an increase in the formation of calcium phosphate complexes in the blood.

When phosphate levels rise, it binds with calcium, which can cause a decline in serum calcium levels, known as hypocalcemia. This hypocalcemia is a key concern in TLS and can contribute to various complications, such as neuromuscular irritability and cardiac issues. Understanding the relationship between phosphorus and calcium is crucial for clinical management, as correcting hypocalcemia may require addressing the underlying hyperphosphatemia.

In contrast, the other options do not reflect the physiological processes involved in TLS. For instance, phosphorus does not inherently increase calcium levels or directly promote red blood cell production, nor does it enhance kidney function in the context of TLS. These roles do not pertain to the interplay of phosphate and calcium during the metabolic imbalances seen in this syndrome.